There are literally thousands of new spyware/adware/malware(s) per day. The Anti-Spyware vendors have research teams dedicated to hunting down, analyzing and adding detection for these to their databases on a daily basis. However, due to the extreme volume of infections and the fact that some infections maybe extremely regional, affecting only users in one certain language, there can be a delay before the infected files reach the research labs, and they are analyzed. Therefore, no Anti-Spyware application can provide 100% detection.

If you suspect that your computer is indeed infected, then you should follow the steps listed in "My computer is infected, what should I do?"